In recent years, both stem cell therapy and fasting have garnered significant attention for their potential health benefits. Individually, each of these approaches has shown promise in promoting healing, regeneration, and overall wellness. However, there is an interesting intersection between fasting and stem cells, with fasting showing some potential to enhance stem cell regeneration.
In this blog, we’ll explore the relationship between stem cell therapy and fasting, the underlying science, and some important considerations to keep in mind.
What is fasting?
Fasting, the practice of abstaining from food for varying periods, has been shown to have numerous health benefits, including improved metabolic health, enhanced brain functioning, and anti-ageing effects. There are several types of fasting, such as intermittent fasting, prolonged fasting (48 hours or more), and time-restricted eating, each with its own regimen and effects.
Although no calories are consumed during fasting, generally, beverages like water and decaffeinated coffee can be consumed to ensure hydration.
Understanding stem cells
Stem cells are undifferentiated or ‘blank’ cells which have a unique ability to develop into specialized cells that the body needs. For instance, they can differentiate into the cells needed to repair damaged tissues, helping to promote the regeneration and healing of this area.
It’s this outstanding regenerative quality that makes stem cells so powerful. When introduced to the body during stem cell therapy, stem cells have the ability to repair and heal a wide range of diseases and conditions, including neurological disorders, tissue injuries, and autoimmune diseases.
The relationship between stem cells and fasting
Some studies have shown that prolonged fasting can increase the functioning and regenerative capacity of stem cells, as well as many other benefits.
In one study using mice, prolonged fasting (48-120 hours) led to the body breaking down a significant amount of white blood cells that weren’t in use. This is to try and save as much energy as possible.
This reduction of white blood cells triggered changes in the signaling pathways of hematopoietic stem cells (which generate blood cells and the immune system). This change shifted dormant stem cells to a state of self-renewal, leading to increased immune system regeneration and regulation. In this sense, prolonged fasting allowed the immune system to essentially redevelop, which in theory, could bring a host of benefits.
Another study also found that fasting dramatically improved how well stem cells can regenerate. In mice that were fasting, a “metabolic shift” occurred, where instead of breaking down glucose, cells begin breaking down fatty acids. This is an evolutionary response to having no glucose (from food) available. This shift changes the cell signaling pathways, encouraging stem cells to further regenerate with greater efficiency.
So, does fasting increase stem cells?
Well, some evidence suggests that fasting increases stem cell activity, but the link between stem cells and fasting isn’t just as straightforward as that. There are several cautions and considerations that must be taken into account.
What are the risks associated with fasting?
Although fasting is associated with numerous benefits, including potential cellular regeneration, fasting can also pose some health risks.
Nutritional deficiencies: prolonged fasting or inadequate nutrient intake during fasting periods can lead to deficiencies in essential vitamins, minerals, and nutrients. Over time, this may cause malnutrition, which can lead to possible symptoms such as:
- fatigue and weakness
- frequent illnesses and infections due to a compromised immune system
- low mood
- poor concentration
- weight loss
- muscle loss due to a lack of protein intake.
Dehydration: when fasting for 24-48 hours (or even longer), water and salt is lost through urine. This can lead to dehydration, which can cause symptoms like headaches and dizziness. More serious cases of dehydration can lead to memory problems and confusion. It’s important to ensure enough water and salt intake during a fast.
Mental health implications: the psychological effects of fasting are yet to be well established. Some evidence shows that fasting can cause mood improvements and decrease negative moods. Whereas other studies have found that fasting can cause cognitive impairments, mood changes, and an increase in negative emotions like irritability, anger, and anxiety.
In some people, fasting behaviors may increase the risk of disordered eating habits, or developing an eating disorder.
Other complications of fasting may include:
- Hormonal disruptions
- Hypoglycemia (low blood sugar)
- Digestive issues
- Headaches
One size does not fit all
Although fasting may offer certain benefits for health and cellular regeneration, it’s important to note that the effects of fasting can vary widely among individuals. Factors like age, health status and genetic predispositions can all influence how effective and safe fasting is, and whether fasting increases stem cells or offers stem cells better regenerative capabilities.
Based on this individual variation, and the risks associated with fasting, it’s crucial that fasting protocols are individualized based on personal factors. Fasting of any kind should only be carried out under medical supervision from a healthcare professional.
Stem cell therapy at Stemwell
The intersection of stem cells and fasting represents an interesting frontier in regenerative medicine and is certainly an area that requires further study. However, it’s essential to approach this combination with careful consideration and medical supervision.
At our state-of-the-art clinic in Bogotá, we are committed to exploring and implementing the latest advancements in regenerative medicine to provide our patients with the best possible care. To learn more about how stem cell therapy can support your health and recovery journey, contact our expert team today.
